HCID 59553878, compound → HCID 135948973, compound

HRID 1170926Notes

Reaction equation

HRID 1170926 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]([CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17](=[O:27])[C:18]2[C:24]([O:25][CH3:26])=[N:23][CH:22]=[CH:21][C:19]=2[N:20]=1)C1C=CC=CC=1>CO.[Pd]>[OH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]([CH2:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:17](=[O:27])[C:18]2[C:24]([O:25][CH3:26])=[N:23][CH:22]=[CH:21][C:19]=2[N:20]=1

Participants

4

Reactant 1

HCID 59553878HCID 59553878, compound

Product 1

HCID 135948973HCID 135948973, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

2-(2-Benzyloxy-phenyl)-5-methoxy-3-phenethyl-3H-pyrido[4,3-d]pyrimidin-4-one dissolved in methanol (0.05M) was subjected to H-cube hydrogenation (room temperature, Pd/C cartridge). Solvent was then removed and product purified on preparative TLC plate to afford the desired 2-(2-Hydroxy-phenyl)-5-methoxy-3-phenethyl-3H-pyrido[4,3-d]pyrimidin-4-one.

Workup

  1. customSolvent was then removed
  2. customproduct purified on preparative TLC plate

Sources & evidence

ORD record
ord-0f22f4f12fce4152bb1da75e2880dce7
Source dataset
uspto-grants-2010_11
Patent number
US07829572B2

Reaction notes

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