反应详情

温度

80 °C

To a solution of 2-(5-(2,5-dimethyl-1H-pyrrol-1-yl)thiazol-4-yl)-3-phenethyl-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one (7 mg, 0.014 mmol) in ethanol was added hydroxylamine hydrochloride (9.82 mg, 0.14 mmol) and the mixture was heated up to 80° C. for 60 hours. The reaction was then concentrated and purified with flash chromatography providing an off-white solid (1.5 mg). 1H NMR (400 MHz, CDCl3) δ 8.72 (d, 1H), 8.02 (s, 1H), 7.52 (d, 1H), 7.30 (m, 5H), 6.93 (s, br, 2H), 4.89 (t, 2H), 3.17 (t, 2H). MS m/z 418.3 (M+H)+.

1. concentrationThe reaction was then concentrated
2. custompurified with flash chromatography