Hydrochloric Acid → HCID 68765845, compound

HRID 1170936Notes

Reaction equation

HRID 1170936 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH:21]S(C(C)(C)C)=O)[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:21])[CH2:9][CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:19])([F:20])[F:18])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59553654HCID 59553654, compound

Product 1

HCID 68765845HCID 68765845, compoundYield 157.6%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 210 mg (0.5 mmol) 2-Methyl-propane-2-sulfinic acid [1-(4-chloro-phenyl)-3-(4-trifluoromethyl-phenyl)-propyl]-amide in methanol (0.5 mL) was added a 4M HCl solution in dioxane (0.5 mLl) at room temperature under argon. The mixture was stirred at room temperature for 30 minutes. The solvent was removed in vacuo. The solid was stirred in ether, filtered and dried to provide 138 mg (78%) of the title compound as white solid. MS (m/e): 313.9 (MH+).

Workup

  1. customThe solvent was removed in vacuo
  2. stirringThe solid was stirred in ether
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-7beeb9c6999f4effaceb9f7a83c9e16c
Source dataset
uspto-grants-2010_11
Patent number
US07829563B2

Reaction notes

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