Hydrochloric Acid → HCID 19829884, compound

HRID 1170944Notes

Reaction equation

HRID 1170944 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:9][CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[CH:6][C:7]=1[F:8].Cl.[CH3:15]O>>[CH3:15][O:12][C:11](=[O:13])[CH2:10][NH:9][C:4]1[CH:5]=[CH:6][C:7]([F:8])=[C:2]([F:1])[CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 28766517HCID 28766517, compound

Product 1

HCID 19829884HCID 19829884, compoundYield 99%

Conditions

Temperature
5 °C

Procedure

Through a suspension of 3,4-difluorophenylglycine (2.00 g, 10.7 mmol) in methanol (100 mL) was passed gaseous hydrochloric acid for 40 min while cooling with an ice-bath to keep ambient temperature. The resulting solution was stirred for 1 h at 5° C. and for 30 min at ambient temperature. Nitrogene was passed through the reaction mixture for 120 min. Concentration afforded the title compound (2.52 g, 99%) as a white solid. MS m/e: 202.2 [M−HCl+H]+).

Workup

  1. customfor 40 min
  2. temperaturewhile cooling with an ice-bath
  3. customto keep ambient temperature
  4. waitNitrogene was passed through the reaction mixture for 120 min
  5. concentrationConcentration

Sources & evidence

ORD record
ord-188beb7e4282409f8aa47718161ec6e4
Source dataset
uspto-grants-2010_11
Patent number
US07829563B2

Reaction notes

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