3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide → N-[4-({2-[[amino(imino)methyl](methyl)amino]pyrimidin-4-yl}oxy)-1-naphthyl]-3-fluoro-5-morpholin-4-ylbenzamide

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Compound is prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and N-methylguanidine according to conditions described in general procedure C. Mp: 155-157° C.; 1H NMR (400 MHz, DMSO-d6) δ 3.19-3.33 (m, 7 H), 3.75-3.78 (m, 4 H), 6.50 (d, J=5.5 Hz, 1 H), 7.04 (d, J=12.0 Hz, 1 H), 7.27 (d, J=9.1Hz, 1 H), 7.34-7.68 (m, 7 H), 7.80 (d, J=8.8 Hz, 1 H), 7.99 (d, J=8.2 Hz, 1 H), 8.29 (d, J=5.5 Hz, 1 H), 10.47 (s, 1 H).

Provenance & Evidence