4-Methylpiperidine → HCID 59553170, compound

HRID 1171300Notes

Reaction equation

HRID 1171300 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](S(C)(=O)=O)[N:20]=2)=[CH:10][CH:9]=1)=[O:6].[CH3:38][CH:39]1[CH2:44][CH2:43][NH:42][CH2:41][CH2:40]1>>[F:1][C:2]1[CH:3]=[C:4]([CH:29]=[C:30]([N:32]2[CH2:37][CH2:36][O:35][CH2:34][CH2:33]2)[CH:31]=1)[C:5]([NH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[C:11]([O:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([N:42]3[CH2:43][CH2:44][CH:39]([CH3:38])[CH2:40][CH2:41]3)[N:20]=2)=[CH:10][CH:9]=1)=[O:6]

Participants

3

Reactant 2

HCID 693814-MethylpiperidineHCID 595530953-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide

Product 1

HCID 59553170HCID 59553170, compound

Procedure

Prepared from 3-fluoro-N-(4-{[2-(methylsulfonyl)pyrimidin-4-yl]oxy}-1-naphthyl)-5-morpholin-4-ylbenzamide and 4-methylpiperidine according to conditions described in general procedure C. Mp: 117-118° C.; 1H NMR (400 MHz, DMSO-d6) δ 0.84-0.94 (m, 5 H), 1.49-1.52 (m, 3 H), 2.67 (t, J=12.0 Hz, 2 H), 3.25 (m, 4 H), 3.73 (m, 4 H), 4.30 (s, 2 H), 6.19-6.20 (m, 1 H), 7.03-7.06 (m, 1 H), 7.27 (d, J=8.4 Hz, 1 H), 7.41-7.63 (m, 5 H), 7.83-7.85 (m, 1 H), 7.98-8.01 (m, 1 H), 8.25-8.27 (m, 1 H), 10.47 (s, 1 H).

Sources & evidence

ORD record
ord-48e4dfd4694043048bbf1981b387af42
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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