Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1171395Generated: October 31, 2026

Piperidin-4-ol → 3-Fluoro-N-{4-[3-(4-hydroxy-piperidin-1-yl)-propoxy]-naphthalen-1-yl}-5-piperidin-1-yl-benzamide

https://huagongshe.com/reaction/1171395

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPiperidin-4-olHCID 79341—
ReactantN-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamideHCID 59553319—
Product3-Fluoro-N-{4-[3-(4-hydroxy-piperidin-1-yl)-propoxy]-naphthalen-1-yl}-5-piperidin-1-yl-benzamideHCID 59553177—

Reaction Steps

Compound is prepared from N-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide and 4-hydroxypiperidine according to conditions described in general procedure L. A yellow powder is produced (0.137 g, 80%). MS: 506 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07829560B2
Source datasetuspto-grants-2010_11
ORD IDord-7d4cb76d67804539bef28846e4799e58
Source noteuspto-grants-2010_11