Piperidin-4-ol → 3-Fluoro-N-{4-[3-(4-hydroxy-piperidin-1-yl)-propoxy]-naphthalen-1-yl}-5-piperidin-1-yl-benzamide

HRID 1171395Notes

Reaction equation

HRID 1171395 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([NH:16][C:17](=[O:31])[C:18]2[CH:23]=[C:22]([N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH:21]=[C:20]([F:30])[CH:19]=2)=[CH:8][CH:7]=1.[OH:32][CH:33]1[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]1>>[F:30][C:20]1[CH:19]=[C:18]([CH:23]=[C:22]([N:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH:21]=1)[C:17]([NH:16][C:9]1[C:10]2[C:15](=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:6]([O:5][CH2:4][CH2:3][CH2:2][N:36]2[CH2:37][CH2:38][CH:33]([OH:32])[CH2:34][CH2:35]2)=[CH:7][CH:8]=1)=[O:31]

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 59553319N-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide

Product 1

HCID 595531773-Fluoro-N-{4-[3-(4-hydroxy-piperidin-1-yl)-propoxy]-naphthalen-1-yl}-5-piperidin-1-yl-benzamide

Procedure

Compound is prepared from N-[4-(3-chloropropoxy)-naphthalen-1-yl]-3-fluoro-5-piperidin-1-yl-benzamide and 4-hydroxypiperidine according to conditions described in general procedure L. A yellow powder is produced (0.137 g, 80%). MS: 506 (M+1).

Workup

  1. customA yellow powder is produced (0.137 g, 80%)

Sources & evidence

ORD record
ord-7d4cb76d67804539bef28846e4799e58
Source dataset
uspto-grants-2010_11
Patent number
US07829560B2

Reaction notes

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