Hydrochloric Acid → HCID 86609436, compound

HRID 1171685Notes

Reaction equation

[ClH:1].C([S:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:8]/[C:7]/1=[CH:25]/[C:26]1[CH:30]=[CH:29][N:28]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[N:27]=1)(=O)C.Cl>>[ClH:1].[CH:15]1([C:13](=[O:14])[CH:12]([N:9]2[CH2:10][CH2:11][CH:6]([SH:5])/[C:7](=[CH:25]\[C:26]3[CH:30]=[CH:29][N:28]([CH2:31][C:32]([O:34][CH2:35][CH3:36])=[O:33])[N:27]=3)/[CH2:8]2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[CH2:17][CH2:16]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86761210HCID 86761210, compound

Product 1

HCID 86609436HCID 86609436, compoundYield 42%

Procedure

(Z)-4-(Acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(ethoxycarbonylmethyl)-1H-pyrazol-3-yl]methylidene}piperidine hydrochloride (0.80 g) was treated with hydrogen chloride in a similar manner to that described in Example 133, and the product was purified by preparative HPLC to afford the free base of the title compound (0.31 g) as a pale yellow foam, which was treated with 4N hydrogen chloride dioxane solution to afford the title compound (0.38 g, yield: 51%) as a pale yellow foam.

Workup

customthe product was purified by preparative HPLC

Sources & evidence

ORD record: ord-88c570326f3c452f8b292cc67516fd90
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07829580B2

Reaction notes

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