Sodium borohydride → HCID 23138766, compound

HRID 1171687Notes

Reaction equation

HRID 1171687 reaction equation
[CH3:1][O:2][C:3]([CH2:5][N:6]1[C:10](/[CH:11]=[C:12]2\[CH2:13][N:14]([C:19]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH2:15][CH2:16][C:17]\2=[O:18])=[N:9][N:8]=[N:7]1)=[O:4].[BH4-].[Na+]>>[CH3:1][O:2][C:3]([CH2:5][N:6]1[C:10](/[CH:11]=[C:12]2\[CH2:13][N:14]([C:19]([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:15][CH2:16][CH:17]\2[OH:18])=[N:9][N:8]=[N:7]1)=[O:4]

Participants

3

Reactant 2

HCID 4311764Sodium borohydrideHCID 23139066HCID 23139066, compound

Product 1

HCID 23138766HCID 23138766, compoundYield 68%

Procedure

Following a procedure similar to that described in Example 150-(d), (E)-3-{[1-(methoxycarbonylmethyl)-1H-tetrazol-5-yl]methylidene}-1-(triphenylmethyl)piperidin-4-one (Example 150-(c), 2.2 g) was reduced with sodium borohydride. Purification gave the title compound (1.5 g, yield: 68%) as a pale yellow amorphous solid.

Workup

  1. customPurification

Sources & evidence

ORD record
ord-9ed2529be2ea479bb11b94d506c217c1
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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