Hydrochloric Acid → HCID 23139104, compound

HRID 1171699Notes

Reaction equation

HRID 1171699 reaction equation
[ClH:1].[CH:2]1([C:5](=[O:32])[CH:6]([N:14]2[CH2:19][CH2:18][CH:17]([SH:20])/[C:16](=[CH:21]/[C:22]3[N:23]=[N:24][N:25]([CH2:27][C:28]([O:30]C)=[O:29])[CH:26]=3)/[CH2:15]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[CH2:4][CH2:3]1.Cl>C(#N)C>[ClH:1].[C:28]([CH2:27][N:25]1[CH:26]=[C:22](/[CH:21]=[C:16]2\[CH2:15][N:14]([CH:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[F:13])[C:5]([CH:2]3[CH2:3][CH2:4]3)=[O:32])[CH2:19][CH2:18][CH:17]\2[SH:20])[N:23]=[N:24]1)([OH:30])=[O:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23138507HCID 23138507, compound

Product 1

HCID 23139104HCID 23139104, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following a procedure similar to that described in Example 134, (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(methoxycarbonylmethyl)-1H-1,2,3-triazol-4-yl]methylidene}-4-sulfanylpiperidine hydrochloride (82.8 mg) was treated with hydrochloric acid and the residue obtained by concentration of the reaction mixture was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 25/75, v/v) to afford the title compound (76.0 mg, yield: 95%) as a colourless amorphous solid.

Workup

  1. customthe residue obtained by concentration of the reaction mixture
  2. customwas purified by preparative HPLC (YMC-Pack ODS-A

Sources & evidence

ORD record
ord-c8bb48b02bea438ab0df79c0f15eeb76
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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