Potassium Carbonate → HCID 23138898, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 151, (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(methoxycarbonylmethyl)-1H-1,2,4-triazol-3-yl]methylidene}piperidine hydrochloride (820 mg) was treated with potassium carbonate and the crude product was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024N hydrochloric acid, 30/70, v/v) to afford the title compound (560 mg, yield: 74%) as a colourless amorphous solid.

Provenance & Evidence