Potassium Carbonate → HCID 23138898, compound

HRID 1171703Notes

Reaction equation

HRID 1171703 reaction equation
[ClH:1].C([S:5][CH:6]1[CH2:11][CH2:10][N:9]([CH:12]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[C:13]([CH:15]2[CH2:17][CH2:16]2)=[O:14])[CH2:8]/[C:7]/1=[CH:25]\[C:26]1[N:30]=[CH:29][N:28]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[N:27]=1)(=O)C.C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[ClH:1].[CH:15]1([C:13](=[O:14])[CH:12]([N:9]2[CH2:10][CH2:11][CH:6]([SH:5])/[C:7](=[CH:25]/[C:26]3[N:30]=[CH:29][N:28]([CH2:31][C:32]([O:34][CH3:35])=[O:33])[N:27]=3)/[CH2:8]2)[C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=2[F:24])[CH2:17][CH2:16]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86609450HCID 86609450, compound

Product 1

HCID 23138898HCID 23138898, compoundYield 74.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following a procedure similar to that described in Example 151, (E)-4-(acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-{[1-(methoxycarbonylmethyl)-1H-1,2,4-triazol-3-yl]methylidene}piperidine hydrochloride (820 mg) was treated with potassium carbonate and the crude product was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024N hydrochloric acid, 30/70, v/v) to afford the title compound (560 mg, yield: 74%) as a colourless amorphous solid.

Workup

  1. customthe crude product was purified by preparative HPLC (YMC-Pack ODS-A

Sources & evidence

ORD record
ord-2725539ff8aa4961a191e0b2343fbaf6
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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