Trifluoroacetic acid → HCID 86609454, compound

Participants

Reaction Steps

Following a procedure similar to that described in Example 132-(f), the crude (E)-4-(acetylsulfanyl)-3-{[1-(methoxycarbonylmethyl)-1H-1,2,4-triazol-5-yl]methylidene}-1-(triphenylmethyl)piperidine (1.57 g) obtained in Example 166-(c) was treated with trifluoroacetic acid in dichloromethane and the product was purified by silica gel chromatography using dichloromethane and methanol (20:1 to 10:1) as eluents to afford the title compound (330 mg, yield: 29%) as a yellow amorphous solid.

Provenance & Evidence