Trifluoroacetic acid → HCID 86609454, compound

HRID 1171709Notes

Reaction equation

HRID 1171709 reaction equation
[C:1]([S:4][CH:5]1[CH2:10][CH2:9][N:8](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH2:7]/[C:6]/1=[CH:30]\[C:31]1[N:35]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[N:34]=[CH:33][N:32]=1)(=[O:3])[CH3:2].[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44]>ClCCl>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[C:1]([S:4][CH:5]1[CH2:10][CH2:9][NH:8][CH2:7]/[C:6]/1=[CH:30]\[C:31]1[N:35]([CH2:36][C:37]([O:39][CH3:40])=[O:38])[N:34]=[CH:33][N:32]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86609446HCID 86609446, compound

Product 1

HCID 86609454HCID 86609454, compoundYield 29%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Following a procedure similar to that described in Example 132-(f), the crude (E)-4-(acetylsulfanyl)-3-{[1-(methoxycarbonylmethyl)-1H-1,2,4-triazol-5-yl]methylidene}-1-(triphenylmethyl)piperidine (1.57 g) obtained in Example 166-(c) was treated with trifluoroacetic acid in dichloromethane and the product was purified by silica gel chromatography using dichloromethane and methanol (20:1 to 10:1) as eluents to afford the title compound (330 mg, yield: 29%) as a yellow amorphous solid.

Workup

  1. customthe product was purified by silica gel chromatography

Sources & evidence

ORD record
ord-510e7ff507144cbc8082916b172252cb
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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