HRID1171713

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31268

Pyrrolidine

C4H9N

反应SMILES：O=C1CCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1

HCID2748414

1-tritylpiperidin-4-one

C24H23NO

反应SMILES：CCOC(=O)Cc1cc(C=O)nn1C(=O)OC(C)(C)C

HCID91115893

未命名化合物

PRODUCTS

产物

$反应SMILES：CCOC(=O)Cc1cc(/C=C2\CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCC2=O)nn1C(=O)OC(C)(C)C$

HCID23138748

未命名化合物

收率 57%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID241

Benzene

C6H6

PROCEDURE

实验过程

Following a procedure similar to that described in Example 132-(c), ethyl [1-(t-butoxycarbonyl)-3-formyl-1H-pyrazol-5-yl]acetate (7.84 g) was subjected to the reaction with 1-(triphenylmethyl)piperidin-4-one in benzene using pyrrolidine. The crude product thus obtained was purified by silica gel chromatography using hexane, ethyl acetate, and dichloromethane (3:1:1) as an eluent to afford the title compound (9.64 g, yield: 57%) as a yellow amorphous solid.

WORKUP

后处理

customThe crude product thus obtained
customwas purified by silica gel chromatography

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-aaf99d07a7194236b33504fbf85e0d61
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07829580B2
来源说明: uspto-grants-2010_11

反应SMILES

[C:1]([O:5][C:6]([N:8]1[C:12]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:10]([CH:19]=O)=[N:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:21]1([C:27]([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[N:28]2[CH2:33][CH2:32][C:31](=[O:34])[CH2:30][CH2:29]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.N1CCCC1>C1C=CC=CC=1>[C:1]([O:5][C:6]([N:8]1[C:12]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:11][C:10](/[CH:19]=[C:32]2\[CH2:33][N:28]([C:27]([C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:29][CH2:30][C:31]\2=[O:34])=[N:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]