HCID 87566833, compound → HCID 86609464, compound

HRID 1171718Notes

Reaction equation

HRID 1171718 reaction equation
[ClH:1].[CH:2]1([C:5](=[O:34])[CH:6]([N:14]2[CH2:19][CH2:18][C@@H:17]([SH:20])/[C:16](=[CH:21]/[C:22]3[CH:26]=[CH:25][N:24]([CH2:27][CH2:28][C:29]([O:31]CC)=[O:30])[N:23]=3)/[CH2:15]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[CH2:4][CH2:3]1>C(#N)C>[ClH:1].[C:29]([CH2:28][CH2:27][N:24]1[CH:25]=[CH:26][C:22](/[CH:21]=[C:16]2\[CH2:15][N:14]([CH:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[F:13])[C:5]([CH:2]3[CH2:4][CH2:3]3)=[O:34])[CH2:19][CH2:18][C@H:17]\2[SH:20])=[N:23]1)([OH:31])=[O:30]

Participants

3

Reactant 1

HCID 87566833HCID 87566833, compound

Product 1

HCID 86609464HCID 86609464, compoundYield 92.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

(4R)-(E)-1-[(1RS)-2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[2-(ethoxycarbonyl)ethyl]-1H-pyrazol-3-yl}methylidene)-4-sulfanylpiperidine hydrochloride (424.2 mg) was subjected to the reaction similar to that described in Example 134 and the crude product thus obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 30/70, v/v) to afford the title compound (369 mg, yield: 92%) as a colourless amorphous solid.

Workup

  1. customthe crude product thus obtained
  2. customwas purified by preparative HPLC (YMC-Pack ODS-A

Sources & evidence

ORD record
ord-2ba68cc46ddc4142a93ff6fadfc5ddb6
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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