HCID 87566833, compound → HCID 86609464, compound

Participants

Reaction Steps

(4R)-(E)-1-[(1RS)-2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[2-(ethoxycarbonyl)ethyl]-1H-pyrazol-3-yl}methylidene)-4-sulfanylpiperidine hydrochloride (424.2 mg) was subjected to the reaction similar to that described in Example 134 and the crude product thus obtained was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N hydrochloric acid, 30/70, v/v) to afford the title compound (369 mg, yield: 92%) as a colourless amorphous solid.

Provenance & Evidence