HRID1171721

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID31268

Pyrrolidine

C4H9N

结构：O=C1CCN(C(c2ccccc2)(c2ccccc2)c2ccccc2)CC1

HCID2748414

1-tritylpiperidin-4-one

C24H23NO

HCID23138686

tert-Butyl (4-formyl-1,3-thiazol-2-yl)carbamate

C9H12N2O3S

PRODUCTS

生成物

$结构：CC(C)(C)OC(=O)Nc1nc(/C=C2\CN(C(c3ccccc3)(c3ccccc3)c3ccccc3)CCC2=O)cs1$

HCID23138600

未命名化合物

收率 36.2%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 132-(c), 2-(t-butoxycarbonylamino)-1,3-thiazole-4-carbaldehyde (3.2 g) was subjected to the reaction with 1-(triphenylmethyl)piperidin-4-one (4.8 g) and pyrrolidine (0.24 ml), and the crude product was purified by silica gel chromatography using hexane, ethyl acetate, and dichloromethane (1:3:1 to 1:5:1) as eluents to afford the title compound (2.8 g, yield: 36%) as an oil.

WORKUP

后处理

customthe crude product was purified by silica gel chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c5ad84445c954988a7a6dc4cfa4c3ba9
来源数据集: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07829580B2
来源说明: uspto-grants-2010_11

反应 SMILES

[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH:14]=O)[N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:16]1([C:22]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[N:23]2[CH2:28][CH2:27][C:26](=[O:29])[CH2:25][CH2:24]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.N1CCCC1>>[C:1]([O:5][C:6]([NH:8][C:9]1[S:10][CH:11]=[C:12](/[CH:14]=[C:27]2\[CH2:28][N:23]([C:22]([C:30]3[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=3)([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[CH2:24][CH2:25][C:26]\2=[O:29])[N:13]=1)=[O:7])([CH3:2])([CH3:3])[CH3:4]