Hydrochloric Acid → HCID 23138591, compound

Participants

Reaction Steps

(E)-4-(Acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({2-[3-(ethoxycarbonyl)propyl]-2H-tetrazol-5-yl}methylidene}piperidine (1.08 g) was treated with hydrogen chloride in ethanol (20 ml) in a similar manner to that described in Example 133. The reaction mixture was concentrated in vacuo, and the residue was purified by chromatography on silica gel using a mixture of ethanol and dichloromethane (2:98 to 10:90) as the eluent to afford the title compound as a pale yellow amorphous solid (976 mg, yield: 91%).

Provenance & Evidence