Hydrochloric Acid → HCID 23138591, compound

HRID 1171734Notes

Reaction equation

HRID 1171734 reaction equation
C([S:4][CH:5]1[CH2:10][CH2:9][N:8]([CH:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[C:12]([CH:14]2[CH2:16][CH2:15]2)=[O:13])[CH2:7]/[C:6]/1=[CH:24]\[C:25]1[N:26]=[N:27][N:28]([CH2:30][CH2:31][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[N:29]=1)(=O)C.[ClH:38]>C(O)C>[ClH:38].[CH:14]1([C:12](=[O:13])[CH:11]([N:8]2[CH2:9][CH2:10][CH:5]([SH:4])/[C:6](=[CH:24]/[C:25]3[N:26]=[N:27][N:28]([CH2:30][CH2:31][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34])[N:29]=3)/[CH2:7]2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23138581HCID 23138581, compound

Product 1

HCID 23138591HCID 23138591, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

(E)-4-(Acetylsulfanyl)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({2-[3-(ethoxycarbonyl)propyl]-2H-tetrazol-5-yl}methylidene}piperidine (1.08 g) was treated with hydrogen chloride in ethanol (20 ml) in a similar manner to that described in Example 133. The reaction mixture was concentrated in vacuo, and the residue was purified by chromatography on silica gel using a mixture of ethanol and dichloromethane (2:98 to 10:90) as the eluent to afford the title compound as a pale yellow amorphous solid (976 mg, yield: 91%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was purified by chromatography on silica gel using
  3. additiona mixture of ethanol and dichloromethane (2:98 to 10:90) as the eluent

Sources & evidence

ORD record
ord-c4d6249f6a2d4b23b52652d10ee69cf2
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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