Hydrochloric Acid → HCID 23138862, compound

Participants

Reaction Steps

In a similar manner to that described in Example 134, (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[4-(ethoxycarbonyl)butyl]-1H-1,2,3-triazol-4-yl}methylidene)-4-sulfanylpiperidine hydrochloride (1.32 g) was treated with 3 N HCl. The crude product was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N HCl, 20/80, v/v) to afford the title compound as a colourless amorphous solid (1.22 g, yield: 97%).

Provenance & Evidence