Hydrochloric Acid → HCID 23138862, compound

HRID 1171744Notes

Reaction equation

HRID 1171744 reaction equation
[ClH:1].[CH:2]1([C:5](=[O:36])[CH:6]([N:14]2[CH2:19][CH2:18][CH:17]([SH:20])/[C:16](=[CH:21]/[C:22]3[N:23]=[N:24][N:25]([CH2:27][CH2:28][CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])[CH:26]=3)/[CH2:15]2)[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[F:13])[CH2:4][CH2:3]1.Cl>C(#N)C>[ClH:1].[C:31]([CH2:30][CH2:29][CH2:28][CH2:27][N:25]1[CH:26]=[C:22](/[CH:21]=[C:16]2\[CH2:15][N:14]([CH:6]([C:7]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[F:13])[C:5]([CH:2]3[CH2:3][CH2:4]3)=[O:36])[CH2:19][CH2:18][CH:17]\2[SH:20])[N:23]=[N:24]1)([OH:33])=[O:32]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23139165HCID 23139165, compound

Product 1

HCID 23138862HCID 23138862, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

In a similar manner to that described in Example 134, (E)-1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-3-({1-[4-(ethoxycarbonyl)butyl]-1H-1,2,3-triazol-4-yl}methylidene)-4-sulfanylpiperidine hydrochloride (1.32 g) was treated with 3 N HCl. The crude product was purified by preparative HPLC (YMC-Pack ODS-A; YMC, eluent: acetonitrile/0.024 N HCl, 20/80, v/v) to afford the title compound as a colourless amorphous solid (1.22 g, yield: 97%).

Workup

  1. customThe crude product was purified by preparative HPLC (YMC-Pack ODS-A

Sources & evidence

ORD record
ord-bf1d3f44c03b4bbdad06d850f8610b99
Source dataset
uspto-grants-2010_11
Patent number
US07829580B2

Reaction notes

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