Ethyl 3-amino-1H-pyrrole-2-carboxylate → 3-{[2-{[tert-Butyl(dimethyl)silyl]oxy}-2-(4-methoxyphenyl)ethyl]amino}-1H-pyrrole-2-carboxylic acid ethyl ester

HRID 1171773Notes

Reaction equation

HRID 1171773 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[CH:9][C:10]=1[NH2:11])=[O:5])[CH3:2].[Si:12]([O:19][CH:20]([C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)[CH:21]=O)([C:15]([CH3:18])([CH3:17])[CH3:16])([CH3:14])[CH3:13]>>[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[CH:9][C:10]=1[NH:11][CH2:21][CH:20]([O:19][Si:12]([C:15]([CH3:16])([CH3:18])[CH3:17])([CH3:13])[CH3:14])[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 2773439Ethyl 3-amino-1H-pyrrole-2-carboxylateHCID 86623127{[tert-Butyl(dimethyl)silyl]oxy}(4-methoxyphenyl)acetaldehyde

Product 1

HCID 670684993-{[2-{[tert-Butyl(dimethyl)silyl]oxy}-2-(4-methoxyphenyl)ethyl]amino}-1H-pyrrole-2-carboxylic acid ethyl esterYield 29%

Procedure

The title compound (0.13 g, 19%) was prepared in accordance with general method A using 3-amino-1H-pyrrole-2-carboxylic acid ethyl ester (0.16 g, 1.07 mmol) and {[tert-butyl(dimethyl)silyl]oxy}(4-methoxyphenyl)acetaldehyde (0.3 g, 1.07 mmol).

Sources & evidence

ORD record
ord-8e9c06c4169b41b6b0cfff119605107b
Source dataset
uspto-grants-2010_11
Patent number
US07829707B2

Reaction notes

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