HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → Solifenacin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Quinuclidinol, (-)- | HCID 91404 | — |
| Reactant | (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2-methylpropan-2-yl ester | HCID 67079183 | — |
| Solvent | Sodium t-butoxide | HCID 23676156 | — |
| Product | Solifenacin | HCID 154059 | 3.9% |
Reaction Steps
In a mixture of 0.38 g of sodium tert-butoxide, 60 ml of toluene and 3 ml of DMF, 2.96 g of (R)-quinuclidin-3-ol was allowed to react with 6.00 g of (S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid 2-methylpropan-2-yl ester for 8 hours while evaporating the solvent, thereby obtaining 0.274 g of a solifenacin-containing composition.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07829715B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-1f9f11c904f3497486a176463ff6083d |
| Source note | uspto-grants-2010_11 |