Hydrogen iodide → 2-[(6-Chloropyridin-3-yl)methyl]tetrahydro-1H-1lambda4-thiophen-1-imine-1-oxide

HRID 1171880Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][S:10]2=[O:14])=[CH:4][N:3]=1.I.[N-:16]=[N+]=[N-].[Na+]>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]([CH2:8][CH:9]2[CH2:13][CH2:12][CH2:11][S:10]2(=[O:14])=[NH:16])=[CH:6][CH:7]=1

Participants

Reactant 3

HCID 24841Hydrogen iodide

HCID 33557Sodium Azide

HCID 592152222-Chloro-5-[(1-oxidotetrahydrothien-2-yl)methyl]-pyridine

Product 1

HCID 592152242-[(6-Chloropyridin-3-yl)methyl]tetrahydro-1H-1lambda4-thiophen-1-imine-1-oxide

Procedure

2-[(6-Chloropyridin-3-yl)methyl]tetrahydro-1H-1λ4-thiophen-1-imine-1-oxide was prepared from 2-chloro-5-[(1-oxidotetrahydrothien-2-yl)methyl]-pyridine by the method as described in Example I-H using NaN3 as the iminating agent.

Sources & evidence

ORD record: ord-07b45bfcc0ee4a5db13369eb7ea5e00f
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07829719B2

Reaction notes

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