Methanol → Ethyl (4'-methylbiphenyl-2-yl)acetate

Participants

Reaction Conditions

Reaction Steps

To a mixture composed of 243.1 mg (1 mmol) of ethyl 2-(2-bromophenyl)acetate, 3.7 ml of toluene, 57.8 mg (0.05 mmol) of tetrakis(triphenylphosphine)palladium and 127.2 mg (1.2 mmol) of anhydrous sodium carbonate are added 169.9 mg (1.25 mmol) of 4-methylphenylboronic acid, followed by addition of 2.21 ml (0.055 mmol) of methanol. The reaction medium is heated at 85° C. for 16 hours with stirring. After cooling, 10 ml of water and 8 ml of ethyl acetate are added with stirring, and the mixture is then filtered through a fluted filter paper. The organic phase is recovered and the aqueous phase is extracted again with ethyl acetate.

Provenance & Evidence