反应详情

温度

85 °C

To a mixture composed of 243.1 mg (1 mmol) of ethyl 2-(2-bromophenyl)acetate, 3.7 ml of toluene, 57.8 mg (0.05 mmol) of tetrakis(triphenylphosphine)palladium and 127.2 mg (1.2 mmol) of anhydrous sodium carbonate are added 169.9 mg (1.25 mmol) of 4-methylphenylboronic acid, followed by addition of 2.21 ml (0.055 mmol) of methanol. The reaction medium is heated at 85° C. for 16 hours with stirring. After cooling, 10 ml of water and 8 ml of ethyl acetate are added with stirring, and the mixture is then filtered through a fluted filter paper. The organic phase is recovered and the aqueous phase is extracted again with ethyl acetate.

1. temperatureAfter cooling
2. stirringwith stirring
3. filtrationthe mixture is then filtered through
4. filtrationa fluted filter paper
5. customThe organic phase is recovered
6. extractionthe aqueous phase is extracted again with ethyl acetate