HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → 4-(Benzyloxy)benzyl (2-bromo-5-fluorophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | (4-(Benzyloxy)phenyl)methanol | HCID 70043 | — |
| Reactant | 2-(2-Bromo-5-fluorophenyl)acetic acid | HCID 2773927 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(Benzyloxy)benzyl (2-bromo-5-fluorophenyl)acetate | HCID 86623774 | — |
Reaction Steps
A suspension of 3 g (2.73 mmol) of Wang resin (p-benzyloxybenzyl alcohol resin, 100-200 mesh) in 49 ml of dichloromethane is stirred (orbital stirring) at room temperature for 15 minutes. 2.8 g (12.0 mmol) of (2-bromo-5-fluorophenyl)acetic acid dissolved in 20 ml of dichloromethane are then added, followed by addition of 0.067 g (0.55 mmol) of 4-dimethylaminopyridine and 1.88 ml (12.0 mol) of N,N′-diisopropylcarbodiimide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07829721B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-418d3fafa14c46bea31126cf9ba3cf3a |
| Source note | uspto-grants-2010_11 |