反应详情

A suspension of 3 g (2.73 mmol) of Wang resin (p-benzyloxybenzyl alcohol resin, 100-200 mesh) in 49 ml of dichloromethane is stirred (orbital stirring) at room temperature for 15 minutes. 2.8 g (12.0 mmol) of (2-bromo-5-fluorophenyl)acetic acid dissolved in 20 ml of dichloromethane are then added, followed by addition of 0.067 g (0.55 mmol) of 4-dimethylaminopyridine and 1.88 ml (12.0 mol) of N,N′-diisopropylcarbodiimide.

1. stirring(orbital stirring) at room temperature for 15 minutes
2. additionare then added