2-Methoxyethylamine → HCID 11628066, compound

HRID 1171892Notes

Reaction equation

CO[C:3]1[C:6](=[O:7])[C:5](=[O:8])[C:4]=1[NH:9][C:10]1[CH:11]=[C:12]([NH:17][C:18]([C:20]2[S:21][CH:22]=[CH:23][C:24]=2[NH:25][CH2:26][C:27]2[C:36]3[C:31](=[CH:32][CH:33]=[CH:34][CH:35]=3)[N:30]=[CH:29][CH:28]=2)=[O:19])[CH:13]=[CH:14][C:15]=1[CH3:16].[CH3:37][O:38][CH2:39][CH2:40][NH2:41]>>[N:30]1[C:31]2[C:36](=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:27]([CH2:26][NH:25][C:24]2[CH:23]=[CH:22][S:21][C:20]=2[C:18]([NH:17][C:12]2[CH:13]=[CH:14][C:15]([CH3:16])=[C:10]([NH:9][C:4]3[C:5](=[O:8])[C:6](=[O:7])[C:3]=3[NH:41][CH2:40][CH2:39][O:38][CH3:37])[CH:11]=2)=[O:19])=[CH:28][CH:29]=1

Participants

Reactant 2

HCID 80182-Methoxyethylamine

HCID 11670524HCID 11670524, compound

Product 1

HCID 11628066HCID 11628066, compound

Procedure

EXAMPLE 46 was prepared according to the procedure described in EXAMPLE 3 using N-{3-[(2-methoxy-3,4-dioxocyclobut-1-en-1-yl)amino]-4-chlorophenyl}-3-[(quinolin-4-ylmethyl)amino]thiophene-2-carboxamide (EXAMPLE 44) and 2-methoxyethylamine instead of dimethylamine. MS (ES+): m/z 541.9 [M+1]

Workup

customEXAMPLE 46 was prepared

Sources & evidence

ORD record: ord-ec3fd88ef84c4e81bce6bc0409c43b31
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07829717B2

Reaction notes

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