Hydrochloric Acid → Hydrochloric Acid

HRID 1172293Notes

Reaction equation

HRID 1172293 reaction equation
[O:1]=[C:2]1[NH:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]1[CH:11]1[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1.[ClH:24]>CCOCC>[ClH:24].[NH:14]1[CH2:13][CH2:12][CH:11]([N:3]2[C:4]3[C:5](=[N:6][CH:7]=[CH:8][CH:9]=3)[NH:10][C:2]2=[O:1])[CH2:16][CH2:15]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 22293220tert-butyl 4-{2-oxo-1H,2H,3H-imidazo[4,5-b]pyridin-1-yl}piperidine-1-carboxylate

Product 2

HCID 313Hydrochloric AcidHCID 22293182Bms-973013

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A solution of tert-butyl 4-(2,3-dihydro-2-oxoimidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (3.39 g, 10.7 mmol) in 2N HCl in Et2O (20 ml) was stirred from 0° C. to RT over 2 h. The solvent was evaporated and the residue triturated with Et2O, filtered washed with Et2O and dried to give the bis-HCl Salt of the desired product (2.62 g). LC/MS (10% to 99%): M/Z (M+H)+ (obs)=219; tR=0.36.

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated with Et2O
  3. filtrationfiltered
  4. washwashed with Et2O
  5. customdried

Sources & evidence

ORD record
ord-9f4bfd970f884a28a8941be053614379
Source dataset
uspto-grants-2010_11
Patent number
US07834000B2

Reaction notes

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