HCID 11589233, compound → HCID 16058859, compound

HRID 1172371Notes

Reaction equation

HRID 1172371 reaction equation
[NH2:1][C@H:2]([C:15](=[O:28])[N:16]1[CH2:21][CH2:20][N:19]([C:22]2[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=2)[CH2:18][CH2:17]1)[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:13])([CH3:12])[CH3:11].[CH3:29][C:30]1[CH:31]=[C:32]([CH2:39][C@@H:40]([NH:44][C:45]([N:47]2[CH2:52][CH2:51][CH:50]([N:53]3[CH2:62][C:61]4[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=4)[NH:55][C:54]3=[O:63])[CH2:49][CH2:48]2)=[O:46])[C:41](O)=[O:42])[CH:33]=[C:34]2[C:38]=1[NH:37][N:36]=[CH:35]2.CC1C=C(C[C@@H](NC(N2CCC(C3C(=O)NC4C(C=3)=CC=CC=4)CC2)=O)C(N[C@H](C(=O)N2CCN(C3C=CN=CC=3)CC2)CCCCNC(=O)OC(C)(C)C)=O)C=C2C=1NN=C2>>[CH3:29][C:30]1[CH:31]=[C:32]([CH2:39][C@@H:40]([NH:44][C:45]([N:47]2[CH2:48][CH2:49][CH:50]([N:53]3[CH2:62][C:61]4[C:56](=[CH:57][CH:58]=[CH:59][CH:60]=4)[NH:55][C:54]3=[O:63])[CH2:51][CH2:52]2)=[O:46])[C:41]([NH:1][C@H:2]([C:15](=[O:28])[N:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:23]=[CH:24][N:25]=[CH:26][CH:27]=3)[CH2:18][CH2:17]2)[CH2:3][CH2:4][CH2:5][CH2:6][NH:7][C:8](=[O:14])[O:9][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:42])[CH:33]=[C:34]2[C:38]=1[NH:37][N:36]=[CH:35]2

Participants

4

Reactant 3

HCID 11589233HCID 11589233, compoundHCID 15953808HCID 15953808, compoundHCID 58657578HCID 58657578, compound

Product 1

HCID 16058859HCID 16058859, compound

Procedure

The title compound was prepared from (S)-tert-butyl 5-amino-6-oxo-6-(4-(pyridin-4-yl)piperazin-1-yl)hexylcarbamate and (R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinazolin-3 (4H)-yl)piperidine-1-carboxamido)propanoic acid using the same procedure as described for tert-butyl (S)-5-((R)-3-(7-methyl-1H-indazol-5-yl)-2-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamido)propanamido)-6-oxo-6-(4-(pyridin-4-yl)piperazin-1-yl)hexylcarbamate. The title compound was obtained in 66% yield. MS (ESI) 850 (M+H) ; Rf=2.07.

Sources & evidence

ORD record
ord-86edeecfe65d4b18b818edcd56658bb7
Source dataset
uspto-grants-2010_11
Patent number
US07834007B2

Reaction notes

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