HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 178519568, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 2-Fluoro-3-(trifluoromethyl)benzoic acid | HCID 518002 | — |
| Reactant | HCID 57562598 | HCID 57562598 | — |
| Product | HCID 178519568 | HCID 178519568 | — |
Reaction Steps
The amidation reaction was performed in the same manner as in Example 3-(2) using 6-((6-(tetrahydro-2H-pyran-2-yloxy)-1,4-diazepan-1-yl)methyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyrazin-2-amine and 2-fluoro-3-(trifluoromethyl)benzoic acid. Next, the deprotection reaction was performed in the same manner as in Example 16-(4) using trifluoroacetic acid to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07834018B2 |
| Source dataset | uspto-grants-2010_11 |
| ORD ID | ord-24aa32ab79be43ea8e01ae5c3a3ec9c9 |
| Source note | uspto-grants-2010_11 |