Trifluoroacetic acid → HCID 178519568, compound

HRID 1172422Notes

Reaction equation

HRID 1172422 reaction equation
O1CCCCC1[O:7][CH:8]1[CH2:14][N:13]([CH2:15][C:16]2[N:21]=[C:20]([NH:22][C:23]3[CH:27]=[CH:26][N:25](COCC[Si](C)(C)C)[N:24]=3)[CH:19]=[N:18][CH:17]=2)[CH2:12][CH2:11][NH:10][CH2:9]1.[F:36][C:37]1[C:45]([C:46]([F:49])([F:48])[F:47])=[CH:44][CH:43]=[CH:42][C:38]=1[C:39](O)=[O:40].FC(F)(F)C(O)=O>>[F:36][C:37]1[C:45]([C:46]([F:47])([F:48])[F:49])=[CH:44][CH:43]=[CH:42][C:38]=1[C:39]([N:10]1[CH2:9][CH:8]([OH:7])[CH2:14][N:13]([CH2:15][C:16]2[N:21]=[C:20]([NH:22][C:23]3[CH:27]=[CH:26][NH:25][N:24]=3)[CH:19]=[N:18][CH:17]=2)[CH2:12][CH2:11]1)=[O:40]

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 5180022-Fluoro-3-(trifluoromethyl)benzoic acidHCID 57562598HCID 57562598, compound

Product 1

HCID 178519568HCID 178519568, compound

Procedure

The amidation reaction was performed in the same manner as in Example 3-(2) using 6-((6-(tetrahydro-2H-pyran-2-yloxy)-1,4-diazepan-1-yl)methyl)-N-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-3-yl)pyrazin-2-amine and 2-fluoro-3-(trifluoromethyl)benzoic acid. Next, the deprotection reaction was performed in the same manner as in Example 16-(4) using trifluoroacetic acid to give the title compound.

Workup

  1. customThe amidation reaction
  2. customNext, the deprotection reaction

Sources & evidence

ORD record
ord-24aa32ab79be43ea8e01ae5c3a3ec9c9
Source dataset
uspto-grants-2010_11
Patent number
US07834018B2

Reaction notes

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