1-Benzoylpiperazine hydrochloride → HCID 57562609, compound

HRID 1172436Notes

Reaction equation

HRID 1172436 reaction equation
CS(O[CH2:6][C:7]1[N:12]=[C:11]([NH:13][C:14]2[S:18][N:17]=[CH:16][N:15]=2)[CH:10]=[CH:9][C:8]=1[CH2:19][O:20][Si](C(C)(C)C)(C)C)(=O)=O.Cl.[C:29]([N:37]1[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[C:29]([N:37]1[CH2:42][CH2:41][N:40]([CH2:6][C:7]2[C:8]([CH2:19][OH:20])=[CH:9][CH:10]=[C:11]([NH:13][C:14]3[S:18][N:17]=[CH:16][N:15]=3)[N:12]=2)[CH2:39][CH2:38]1)(=[O:36])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

3

Reactant 2

HCID 122033511-Benzoylpiperazine hydrochlorideHCID 57562669HCID 57562669, compound

Product 1

HCID 57562609HCID 57562609, compound

Procedure

The amination reaction was performed in the same manner as in Example 16-(3) using 6-(methanesulfonyloxymethyl)-5-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-(1,2,4-thiadiazol-5-yl)pyridin-2-amine and 1-benzoylpiperazine hydrochloride obtained in the same manner as in Reference Example 1. Then, the deprotection reaction was performed in the same manner as in Example 5-(3) to give the title compound.

Workup

  1. customThe amination reaction
  2. customobtained in the same manner as in Reference Example 1
  3. customThen, the deprotection reaction

Sources & evidence

ORD record
ord-9ff7d94d79ef45a591190e586e473283
Source dataset
uspto-grants-2010_11
Patent number
US07834018B2

Reaction notes

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