Hydrochloric Acid → HCID 178479673, compound

HRID 1172445Notes

Reaction equation

HRID 1172445 reaction equation
[F:1][C:2]1[C:28]([C:29]([F:32])([F:31])[F:30])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5].[ClH:33]>C(O)C>[ClH:33].[F:1][C:2]1[C:28]([C:29]([F:31])([F:30])[F:32])=[CH:27][CH:26]=[CH:25][C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([CH2:12][C:13]2[N:18]=[C:17]([NH:19][C:20]3[CH:24]=[CH:23][NH:22][N:21]=3)[CH:16]=[N:15][CH:14]=2)[CH2:8][CH2:7]1)=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178519567HCID 178519567, compound

Product 1

HCID 178479673HCID 178479673, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

19.8 g of 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine (Example 44) was suspended in 200 ml of ethanol, and aqueous hydrogen chloride solution (1.0 M, 44.1 ml) was added thereto. The reaction mixture was stirred at room temperature for 1 hour and then evaporated. The resulting residue was solidified with 200 ml of heptane, evaporated and dried to give 6-((4-(2-fluoro-3-(trifluoromethyl)benzoyl)piperazin-1-yl)methyl)-N-1H-pyrazol-3-ylpyrazin-2-amine hydrochloride.

Workup

  1. customevaporated
  2. customevaporated
  3. customdried

Sources & evidence

ORD record
ord-ad21d87a46894380a0a7b606a88b1a1a
Source dataset
uspto-grants-2010_11
Patent number
US07834018B2

Reaction notes

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