Lactic Acid → HCID 178473662, compound

HRID 1172580Notes

Reaction equation

HRID 1172580 reaction equation
[CH3:1][O:2]/[N:3]=[C:4]1\[CH2:5][N:6]([C:11]2[N:16]=[C:15]3[N:17]([CH:25]4[CH2:27][CH2:26]4)[CH:18]=[C:19]([C:22]([OH:24])=[O:23])[C:20](=[O:21])[C:14]3=[CH:13][C:12]=2[F:28])[CH2:7][CH:8]\1[CH2:9][NH2:10].C(Cl)Cl.[C:32]([OH:37])(=[O:36])[CH:33]([CH3:35])[OH:34]>C(O)C>[CH3:1][O:2]/[N:3]=[C:4]1\[CH2:5][N:6]([C:11]2[N:16]=[C:15]3[N:17]([CH:25]4[CH2:27][CH2:26]4)[CH:18]=[C:19]([C:22]([OH:24])=[O:23])[C:20](=[O:21])[C:14]3=[CH:13][C:12]=2[F:28])[CH2:7][CH:8]\1[CH2:9][NH2:10].[C:32]([O-:37])(=[O:36])[CH:33]([CH3:35])[OH:34]

Participants

5

Reactant 3

HCID 612Lactic AcidHCID 6344DichloromethaneHCID 9571107Gemifloxacin

Product 1

HCID 178473662HCID 178473662, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
10 °C

Procedure

Gemifloxacin free base (3 gm) is added to methylene dichloride (65 ml) at 25-30° C., ethanol (20 ml) is added to form a clear solution. To the solution, lactic acid (0.6ml) is added at 25-30° C., stirred for 1 hour and then cooled to 10° C. Filtered the solid and dried at 50-l 55° C. to give 3 gm of gemifloxacin lactate (HPLC Purity: 99.93%).

Workup

  1. customto form a clear solution
  2. filtrationFiltered the solid
  3. dry with materialdried at 50-l 55° C.

Sources & evidence

ORD record
ord-4c010d5faa2d4cef83260570441194a1
Source dataset
uspto-grants-2010_11
Patent number
US07834027B2

Reaction notes

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