Ethanol → HCID 178502622, compound

HRID 1172581Notes

Reaction equation

HRID 1172581 reaction equation
[CH3:1][O:2]/[N:3]=[C:4]1\[CH2:5][N:6]([C:11]2[N:16]=[C:15]3[N:17]([CH:25]4[CH2:27][CH2:26]4)[CH:18]=[C:19]([C:22]([OH:24])=[O:23])[C:20](=[O:21])[C:14]3=[CH:13][C:12]=2[F:28])[CH2:7][CH:8]\1[CH2:9][NH2:10].C(Cl)Cl.C(O)C>C(O)=O>[CH3:1][O:2]/[N:3]=[C:4]1\[CH2:5][N:6]([C:11]2[N:16]=[C:15]3[N:17]([CH:25]4[CH2:27][CH2:26]4)[CH:18]=[C:19]([C:22]([OH:24])=[O:23])[C:20](=[O:21])[C:14]3=[CH:13][C:12]=2[F:28])[CH2:7][CH:8]\1[CH2:9][NH2:10].[CH:22]([O-:24])=[O:23]

Participants

5

Reactant 3

HCID 702EthanolHCID 6344DichloromethaneHCID 9571107Gemifloxacin

Product 1

HCID 178502622HCID 178502622, compoundYield 155.4%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
10 °C

Procedure

Gemifloxacin free base (3 gm) is added to methylene dichloride (65 ml) at 25-30 ° C., ethanol (20 ml) is added to form a clear solution. To the solution, formic acid (0.4ml) is added at 25-l 30° C., stirred for 1 hour and then cooled to 10° C. Filtered the solid and dried at 50- 55° C. to give 2.6 gm of gemifloxacin formate (HPLC Purity: 99.93%).

Workup

  1. customto form a clear solution
  2. filtrationFiltered the solid
  3. customdried at 50- 55° C.

Sources & evidence

ORD record
ord-6497c70a89c54ef5823400b1f546be9a
Source dataset
uspto-grants-2010_11
Patent number
US07834027B2

Reaction notes

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