Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Gemifloxacin | HCID 9571107 | — |
| Solvent | Formic Acid | HCID 284 | — |
| Product | HCID 178502622 | HCID 178502622 | 155.4% |
Reaction Steps
Gemifloxacin free base (3 gm) is added to methylene dichloride (65 ml) at 25-30 ° C., ethanol (20 ml) is added to form a clear solution. To the solution, formic acid (0.4ml) is added at 25-l 30° C., stirred for 1 hour and then cooled to 10° C. Filtered the solid and dried at 50- 55° C. to give 2.6 gm of gemifloxacin formate (HPLC Purity: 99.93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07834027B2 |
|---|
| Source dataset | uspto-grants-2010_11 |
|---|
| ORD ID | ord-6497c70a89c54ef5823400b1f546be9a |
|---|
| Source note | uspto-grants-2010_11 |
|---|
