2-Fluoro-3-methylbenzenepropanol → HCID 57659624, compound

HRID 1172599Notes

Reaction equation

HRID 1172599 reaction equation
[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH2:11][OH:12].C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl>[F:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:9][CH2:10][CH:11]=[O:12]

Participants

4

Reactant 2

HCID 576596102-Fluoro-3-methylbenzenepropanolHCID 178418287HCID 178418287, compound

Product 1

HCID 57659624HCID 57659624, compoundYield 60.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

According to procedures described above, 3-(2-fluoro-3-methyl-phenyl)-propan-1-ol (300 mg, 1.78 mmol) was oxidized by PCC in DCM to give 178 mg (60%) of 3-(2-fluoro-3-methyl-phenyl)-propionaldehyde. LC-MS: tR=0.86 min; [M+H]+=no ionization.

Sources & evidence

ORD record
ord-7efa0f6ded074a87a60a96d61ddc5b35
Source dataset
uspto-grants-2010_11
Patent number
US07834028B2

Reaction notes

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