Dimethylformamide → 5-Ethynyl-N-{3-[3-methyl-4-(3-oxomorpholin-4-yl)phenylcarbamoyl]-tetrahydrofuran-3-yl}thiophene-2-carboxamide

HRID 117265Notes

Reaction equation

HRID 117265 reaction equation
[B-:34]([F:35])([F:36])([F:37])[F:38].[C:1](#[CH:2])[c:3]1[cH:4][cH:5][c:6]([C:8](=[O:9])[OH:10])[s:7]1.[NH2:11][C:12]1([C:17](=[O:18])[NH:19][c:20]2[cH:21][c:22]([CH3:33])[c:23]([N:26]3[C:27](=[O:32])[CH2:28][O:29][CH2:30][CH2:31]3)[cH:24][cH:25]2)[CH2:13][O:14][CH2:15][CH2:16]1.[O:56]=[CH:57][N:58]([CH3:59])[CH3:60].[n:39]1([O:40][C:41]([N:42]([CH3:43])[CH3:44])=[N+:45]([CH3:46])[CH3:47])[c:48]2[cH:49][cH:50][cH:51][cH:52][c:53]2[n:54][n:55]1>>[C:1](#[CH:2])[c:3]1[cH:4][cH:5][c:6]([C:8](=[O:10])[NH:11][C:12]2([C:17](=[O:18])[NH:19][c:20]3[cH:21][c:22]([CH3:33])[c:23]([N:26]4[C:27](=[O:32])[CH2:28][O:29][CH2:30][CH2:31]4)[cH:24][cH:25]3)[CH2:13][O:14][CH2:15][CH2:16]2)[s:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 26255TetrafluoroborateHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 450847505-Ethynylthiophene-2-carboxylic acidHCID 688706453-amino-N-[3-methyl-4-(3-oxomorpholin-4-yl)phenyl]tetrahydro-furan-3-carboxamide

Product 1

HCID 116121845-Ethynyl-N-{3-[3-methyl-4-(3-oxomorpholin-4-yl)phenylcarbamoyl]-tetrahydrofuran-3-yl}thiophene-2-carboxamide

Sources & evidence

ORD record
ord-820e233a16fc4576bb79e1f0c7791d98
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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