Ethanol → 5-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine

HRID 1172656Notes

Reaction equation

HRID 1172656 reaction equation
C(=O)([O-])[O-].[K+].[K+].C(O)C.Cl[C:11]1[C:16]([I:17])=[CH:15][N:14]=[C:13]([S:18][CH3:19])[N:12]=1.[CH3:20][NH:21][NH2:22]>O>[I:17][C:16]1[C:11]([N:21]([CH3:20])[NH2:22])=[N:12][C:13]([S:18][CH3:19])=[N:14][CH:15]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 6061MethylhydrazineHCID 11430Potassium CarbonateHCID 136365194-Chloro-5-iodo-2-(methylthio)pyrimidine

Product 1

HCID 223239775-Iodo-4-(1-methylhydrazino)-2-methylthiopyrimidine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

603 mg of potassium carbonate was added to ethanol (15 mL) solution of 1.25 g of 4-chloro-5-iodo-2-(methylthio)pyrimidine, and with cooling with ice, 0.28 mL of methylhydrazine was dropwise added thereto. This was stirred overnight at room temperature, then water was added thereto, and the precipitated crystal was taken out through filtration and dried to obtain 851 mg of the entitled compound as a white solid.

Workup

  1. additionwas dropwise added
  2. filtrationthe precipitated crystal was taken out through filtration
  3. customdried

Sources & evidence

ORD record
ord-afb4fcc0216e4203ba49a5451e308fd5
Source dataset
uspto-grants-2010_11
Patent number
US07834019B2

Reaction notes

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