HCID 59556306, compound → HCID 59556317, compound

HRID 1172665Notes

Reaction equation

HRID 1172665 reaction equation
[F:1][C:2]([F:23])([CH:21]=[CH2:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][CH:11]=2)=[N:7][C:6]=1[CH3:20])[OH:4]>C(OCC)(=O)C.[Pd]>[F:23][C:2]([F:1])([CH2:21][CH3:22])[CH:3]([C:5]1[S:9][C:8]([C:10]2[CH:11]=[CH:12][C:13]([C:16]([F:17])([F:18])[F:19])=[CH:14][CH:15]=2)=[N:7][C:6]=1[CH3:20])[OH:4]

Participants

4

Reactant 1

HCID 59556306HCID 59556306, compound

Product 1

HCID 59556317HCID 59556317, compoundYield 96.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

740 mg 2,2-Difluoro-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-but-3-en-1-ol were dissolved in 50 ml ethyl acetate. 50 mg palladium (5% on charcoal) were added and the reaction mixture stirred at room temperature under a hydrogen atmosphere. After three hours the catalyst was filtered off and the filtrate evaporated in vacuo to obtain 720 mg 2,2-Difluoro-1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-butan-1-ol as a white solid.

Workup

  1. filtrationAfter three hours the catalyst was filtered off
  2. customthe filtrate evaporated in vacuo

Sources & evidence

ORD record
ord-26ff59966e054b88a6bc71f0679c9e2e
Source dataset
uspto-grants-2010_11
Patent number
US07834030B2

Reaction notes

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