Dichloromethane → N-[7-(ethyl-piperidin-4-ylmethyl-amino)-5,6,7,8-tetrahydro-naphthalen-2-yl]-4-methanesulfonyl-benzamide

HRID 117269Notes

Reaction equation

HRID 117269 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([CH:16]2[CH2:17][c:18]3[cH:19][c:20]([NH:26][C:27]([c:28]4[cH:29][cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]4)=[O:38])[cH:21][cH:22][c:23]3[CH2:24][CH2:25]2)[CH2:39][CH3:40])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[CH2:48]([Cl:49])[Cl:50].[OH:41][C:42]([C:43]([F:44])([F:45])[F:46])=[O:47]>>[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][N:15]([CH:16]2[CH2:17][c:18]3[cH:19][c:20]([NH:26][C:27]([c:28]4[cH:29][cH:30][c:31]([S:34](=[O:35])(=[O:36])[CH3:37])[cH:32][cH:33]4)=[O:38])[cH:21][cH:22][c:23]3[CH2:24][CH2:25]2)[CH2:39][CH3:40])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 686234154-({Ethyl-[7-(4-methanesulfonyl-benzoylamino)-1,2,3,4-tetrahydro-naphthalen-2-yl]-amino}-methyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 11248400N-[7-(ethyl-piperidin-4-ylmethyl-amino)-5,6,7,8-tetrahydro-naphthalen-2-yl]-4-methanesulfonyl-benzamide

Sources & evidence

ORD record
ord-676618b38df342c88791f687d389ef58
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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