Hydrochloric Acid → HCID 66679001, compound

HRID 1172736Notes

Reaction equation

HRID 1172736 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[O:18][N:17]=[C:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)[N:15]=2)[CH2:9]1)=O)(C)(C)C.[ClH:27]>>[ClH:27].[CH3:26][O:25][C:22]1[CH:21]=[CH:20][C:19]([C:16]2[N:15]=[C:14]([CH:10]3[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]3)[O:18][N:17]=2)=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 66618584HCID 66618584, compound

Product 1

HCID 66679001HCID 66679001, compoundYield 100%

Procedure

3-[3-(4-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine-1-carboxylic acid tert-butyl ester (0.39 g, 1.08 mmol) was dissolved in 2 ml of 4N HCl (dioxane solution). The resulting reaction mixture was stirred at R.T. for 1 h and concentrated to afford 0.320 g (100%) of 3-[3-(4-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-piperidine hydrochloride as a brown solid.

Workup

  1. customThe resulting reaction mixture
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-d7888590f9e74f89bd23f1f19aeaf5cf
Source dataset
uspto-grants-2010_11
Patent number
US07834035B2

Reaction notes

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