Hydrochloric Acid → HCID 66618519, compound

HRID 1172757Notes

Reaction equation

HRID 1172757 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][C@H:10]([C:14](=[O:23])[NH:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)[CH2:9]1)=O)(C)(C)C.[ClH:24]>ClCCl>[ClH:24].[F:22][C:19]1[CH:18]=[CH:17][C:16]([NH:15][C:14]([C@H:10]2[CH2:11][CH2:12][CH2:13][NH:8][CH2:9]2)=[O:23])=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 42053071HCID 42053071, compound

Product 1

HCID 66618519HCID 66618519, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a cooled solution of (S)-3-(4-fluoro-phenylcarbamoyl)-piperidine-1-carboxylic acid tert-butyl ester (0.34 g, 1.05 mmol) in dichloromethane (5 mL) was added dropwise 5.2 mL of HCl 4N (dioxane solution) and the solution was stirred at R.T. for 45 min. The solvent was evaporated under reduced pressure to give the title compound as a white solid (0.252 g).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-bb1011851aac49e3b038a26442636074
Source dataset
uspto-grants-2010_11
Patent number
US07834035B2

Reaction notes

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