反应详情

温度

25 °C

A mixture of the phenol from step 2 (16.5 g, 75 mmol), allyl bromide (10.8 g, 90 mmol) and cesium carbonate (48.7 g, 150 mmol) in DMF(300 mL) was stirred at 25° C. for 6 h. The mixture was poured into water (1.0 L) and extracted with ethyl acetate (2×200 mL). The combined organic phase was washed with water (3×100 mL), dried over magnesium sulfate and concentrated. The crude product was used directly in the next step.

1. extractionextracted with ethyl acetate (2×200 mL)
2. washThe combined organic phase was washed with water (3×100 mL)
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated