HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1172828Generated: October 31, 2026
Cesium carbonate → 6-Chloro-3-[4-(4-chlorophenoxy)-2-propylphenyl]-5-methoxy-1,2-benzisoxazole
https://huagongshe.com/reaction/1172828
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (NZ)-N-[(4-chloro-2-fluoro-5-methoxyphenyl)-[4-(4-chlorophenoxy)-2-propylphenyl]methylidene]hydroxylamine | HCID 87541464 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Chloro-3-[4-(4-chlorophenoxy)-2-propylphenyl]-5-methoxy-1,2-benzisoxazole | HCID 68692116 | — |
Reaction Steps
A mixture of the oxime from Step 4 (1.2 g, 2.7 mmol) and cesium carbonate (1.7 g, 5.4 mmol) in DMF (20 mL) was stirred at 80° C. for 18 h. The reaction was diluted with ethyl acetate and washed with water. The crude product was purified by chromatography on silica gel to give the title product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07834036B2 |
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| Source dataset | uspto-grants-2010_11 |
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| ORD ID | ord-aba7241ea3054d88bafb5dc525a7eefb |
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| Source note | uspto-grants-2010_11 |
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