HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Chloroacetyl chloride → HCID 57624569, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Chloroacetyl chloride | HCID 6577 | — |
| Edukt | 4-Methylmorpholine | HCID 7972 | — |
| Edukt | Methyl 5-amino-1-benzothiophene-2-carboxylate | HCID 2824064 | — |
| Lösungsmittel | Water | HCID 962 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Lösungsmittel | Tetrahydrofurane dichloromethane | HCID 21919333 | — |
| Produkt | HCID 57624569 | HCID 57624569 | — |
Reaktionsschritte
To a solution of 5-amino-benzo[b]thiophene-2-carboxylic acid methyl ester (989 mg, 4.79 mmol) in CH2Cl2/THF (5/5 mL) was added NMM (630 μL, 5.73 mmol) and chloroacetylchloride (415 μL, 5.25 mmol). After stirring 2.5 h, the mixture was diluted with EtOAc and H2O, and the solid was filtered yielding a pale-white solid, which was used without further purification. MS: cal'd (MH+) 284, exp (MH+) 284.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07834034B2 |
| Quelldatensatz | uspto-grants-2010_11 |
| ORD ID | ord-670e5bac1978409b8727b163260c22d0 |
| Quellennotiz | uspto-grants-2010_11 |